Visipaque 270
Visipaque 270 - General Information
Visipaque is commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents.
Pharmacology of Visipaque 270
Visipaque 270 is a contrast agent commonly used during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. It is an iso-osmolar contrast agent, with an osmolality of 290 mOsm/kg H20, the same as blood.
Additional information about Visipaque 270
Visipaque 270 Indication: Used as a contrast agent during coronary angiography.
Mechanism Of Action: Organic iodine compounds attenuate x-rays as they pass through the body, thereby allowing the body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. After intravascular administration, iodixanol makes opaque those internal structures in its path of flow, allowing their visualization until significant hemodilution and elimination occur.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Iodixanol
Synonyms: Indixanol; Iodixanolum
Drug Category: Contrast Media
Drug Type: Small Molecule; Approved
Other Brand Names containing Iodixanol: Visipaque; Visipaque 270; Visipaque 320;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Negligible
Biotransformation: Excreted unchanged
Half Life: 2.1 hours. In patients with significantly impaired renal function (mean creatinine clearance rate, 9.91 [± 3.58] mL per minute), the plasma half-life is increased to 23 hours.
Dosage Forms of Visipaque 270: Solution Intra-arterial
Chemical IUPAC Name: 5-[acetyl-[3-[acetyl-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl]amino]-2-hydroxypropyl]amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
Chemical Formula: C35H44I6N6O15
Iodixanol on Wikipedia: https://en.wikipedia.org/wiki/Iodixanol
Organisms Affected: Humans and other mammals
